With a packed crowd at Carrara Stadium roaring, Simbine blazed down the straight and crossed ahead of team mate Henricho Bruintjies in 10.03 seconds.
Usain Bolt will fine-tune his preparations for the Rio Olympics by competing at the Anniversary Games in London on July 22.
Jamaica's former world champion Yohan Blake sailed into the final of the 100 metres at the Commonwealth Games on Sunday, living up to his top billing on the opening day of the athletics at the Gold Coast.
The Jamaican clocked 9.98 seconds into a slight breeze at the Kamila Skolimowska Memorial in front of a 20,000 crowd on a new track laid down the side of the infield.
Usain Bolt led three Jamaicans into the final of the men's 200 metres on Friday as the World record holder seeks a third successive world title at his favourite distance.
Usain Bolt stretched, stifled a yawn and, almost apologetically, extracted his giant frame from his blocks before strolling through his heat as he began his bid for a third successive world 200 metres title on Friday.
Usain Bolt completed yet another crushing sprint double on Saturday and hardly needed to extend himself to achieve it as he took his third successive world 200 metres title in the year's fastest time of 19.66 seconds - easing down.
Usain Bolt of Jamaica won the men's 200 meters gold for the third successive Summer Games on Thursday, crossing the line in 19.78 seconds at the Rio Olympic stadium.
Akeem Bloomfield announced himself as the latest 'next big thing' from Jamaica
A summary of sports events and sports persons, who made news on Sunday